Title

Novel Arylazoarylmethane as Potential Inhibitor of Macrophage Migration Inhibitory Factor

Publication Date

January 2014

Journal Title

Archiv Der Pharmazie

Abstract

Macrophage migration inhibitory factor (MIF), a cytokine involved in the pathogenesis of sepsis, diabetes, asthma, arthritis, and cancer, has an enzymatic active site that has proven to be an effective target for small molecule-based inhibitors. Herein, we describe the synthesis of a novel arylazoaryl-methane compound (3) from a known arylhydrazone MIF inhibitor (2). This new compound has improved stability and in vivo biological activity.

Volume Number

347

Issue Number

2

Pages

104-107

Document Type

Article

Facility

School of Medicine

Primary Department

Molecular Medicine

Additional Departments

Medicine

PMID

WOS:000337246300004

DOI

10.1002/ardp.201300243

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