Title
Novel Arylazoarylmethane as Potential Inhibitor of Macrophage Migration Inhibitory Factor
Publication Date
2014
Journal Title
Archiv Der Pharmazie
Abstract
Macrophage migration inhibitory factor (MIF), a cytokine involved in the pathogenesis of sepsis, diabetes, asthma, arthritis, and cancer, has an enzymatic active site that has proven to be an effective target for small molecule-based inhibitors. Herein, we describe the synthesis of a novel arylazoaryl-methane compound (3) from a known arylhydrazone MIF inhibitor (2). This new compound has improved stability and in vivo biological activity.
Volume Number
347
Issue Number
2
Pages
104-107
Document Type
Article
Status
Faculty; Northwell Researcher
Facility
School of Medicine; Northwell Health
Primary Department
Molecular Medicine
Additional Departments
General Internal Medicine; Obstetrics and Gynecology
PMID
DOI
10.1002/ardp.201300243