Title

Is human papillomavirus and p16 expression associated with survival outcomes in nasopharyngeal cancer?: A systematic review and meta-analysis

Publication Date

2018

Journal Title

AMERICAN JOURNAL OF OTOLARYNGOLOGY

Abstract

© 2018 Elsevier Inc. Introduction: Human papillomavirus (HPV) is a known prognostic indicator in oropharyngeal cancer. Not much is known about the prognostic role of HPV in Nasopharyngeal cancer (NPC). Here, we performed a systematic review and meta-analysis of the literature to investigate if HPV status was a prognostic factor for NPC. Methods: PubMed (via the web), Embase, Scopus, and the Cochrane Library were searched. A systematic review and meta-analysis was done to generate the pooled Hazard Ratios (HR) for Overall Survival (OS). Results: A total of 7 studies from 2014 to 2018, reporting data on 2646 patients (range 43–1328) were included in this meta-analysis. The pooled data showed that HPV/p16 status was not associated with OS in NPC with HR of 0.77 (95% CI: 0.55–1.09, p = 0.14). The test for heterogeneity showed little to no heterogeneity of results (I2 = 4%, p = 0.38). Subgroup analysis showed that in large sample sizes, HPV was significantly associated with survival. Conclusion: Despite the finding in the pooled HR, we could not draw a definitive conclusion as to the prognostic significance of HPV in NPC. Recommendations for future research are given.

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Otolaryngology

Additional Departments

Neurosurgery, Science Education

DOI

10.1016/j.amjoto.2018.07.005

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