Is human papillomavirus and p16 expression associated with survival outcomes in nasopharyngeal cancer?: A systematic review and meta-analysis

Publication Date

2018

Journal Title

Am J Otolaryngol

Abstract

© 2018 Elsevier Inc. Introduction: Human papillomavirus (HPV) is a known prognostic indicator in oropharyngeal cancer. Not much is known about the prognostic role of HPV in Nasopharyngeal cancer (NPC). Here, we performed a systematic review and meta-analysis of the literature to investigate if HPV status was a prognostic factor for NPC. Methods: PubMed (via the web), Embase, Scopus, and the Cochrane Library were searched. A systematic review and meta-analysis was done to generate the pooled Hazard Ratios (HR) for Overall Survival (OS). Results: A total of 7 studies from 2014 to 2018, reporting data on 2646 patients (range 43–1328) were included in this meta-analysis. The pooled data showed that HPV/p16 status was not associated with OS in NPC with HR of 0.77 (95% CI: 0.55–1.09, p = 0.14). The test for heterogeneity showed little to no heterogeneity of results (I2 = 4%, p = 0.38). Subgroup analysis showed that in large sample sizes, HPV was significantly associated with survival. Conclusion: Despite the finding in the pooled HR, we could not draw a definitive conclusion as to the prognostic significance of HPV in NPC. Recommendations for future research are given.

Volume Number

39

Issue Number

6

Pages

764-770

Document Type

Article

Status

Faculty, SOM Student

Facility

School of Medicine

Primary Department

Otolaryngology

Additional Departments

Neurosurgery; Science Education

PMID

30029797

DOI

10.1016/j.amjoto.2018.07.005

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