Economic analysis of rapid multiplex polymerase chain reaction testing for meningitis/encephalitis in pediatric patients
© 2018 Future Medicine Ltd. Aim: We assessed the possible economic impact of a rapid test in pediatric patients with suspected community-acquired meningitis/encephalitis. Materials & methods: Modeling simulated diagnosis, clinical decisions, resource use/costs of standard of care (SOC) and two cerebrospinal fluid testing strategies using FilmArray®(FA), a US FDA-cleared system that provides results in approximately 1 h. Results: Pathogens detected by FA caused approximately 75% of cases, 97% of which would be accurately diagnosed with FA. Mean cost/case ranged from 17,599 to 22,025. Syndromic testing is less expensive than SOC. Testing all suspected cases yielded greater savings (3481/case) than testing only those with abnormal cerebrospinal fluid (2157/case). Conclusion: Greater economic benefits are achievable with syndromic testing of all cases, rather than SOC or targeted syndromic testing.
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School of Medicine
Pathology and Laboratory Medicine
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