Publication Date
2015
Journal Title
Horm Behav
Abstract
This article is part of a Special Issue "Estradiol and Cognition". Memory processing is presumed to depend on synaptic plasticity, which appears to have a role in mediating the acquisition, consolidation, and retention of memory. We have studied the relationship between estrogen, recognition memory, and dendritic spine density in the hippocampus and medial prefrontal cortex, areas critical for memory, across the lifespan in female rodents. The present paper reviews the literature on dendritic spine plasticity in mediating both short and long term memory, as well as the decreased memory that occurs with aging and Alzheimer's disease. It also addresses the role of acute and chronic estrogen treatments in these processes.
Volume Number
74
Pages
28-36
Document Type
Article
EPub Date
2015/05/21
Status
Faculty
Facility
School of Medicine
Primary Department
Science Education
Additional Departments
Molecular Medicine
PMID
DOI
10.1016/j.yhbeh.2015.05.004
Included in
Hormones, Hormone Substitutes, and Hormone Antagonists Commons, Psychological Phenomena and Processes Commons