Publication Date
2014
Journal Title
Schizophrenia Research
Abstract
Background: Tardive dyskinesia (TD) is a serious long-term consequence of antipsychotic treatment. Since brain-derived neurotrophic factor (BDNF) has potent neurotrophic activity, genetic alterations in the BDNF gene may affect antipsychotic-induced TD. Methods: Searching PubMed and Web of Science until 05/31/13, we conducted a systematic review and a meta-analysis of the effects of BDNF Val66Met polymorphism on antipsychotic-induced TD. Pooled odds ratio was calculated to assess the effects of BDNF Val66Met polymorphism on TD occurrence. Additionally, pooled standardized mean differences (Hedges'g) were calculated to assess the effects on Abnormal Involuntary Movement Scale (AIMS) total score. Results: Out of 699 potentially eligible hits, 6 studies (N = 1740, mean age = 46.0 +/- 10.4 years; males = 73.1%; Asians = 80.5%, Caucasians = 19.5%; schizophrenia = 96.2%) were included in this meta-analysis. Pooling data from all studies, no significant associations were found between BDNF Val66Met polymorphism and TD (p = 0.82) or AIMS total scores (p = 0.11). However, in studies including only Caucasians (n = 339), Met allele carriers had significantly higher AIMS total scores (Hedges' g = 0.253, 95% confidence interval = 0.030 to 0.476, p = 0.026) and non-significantly higher TD occurrence (p = 0.127). Conversely, there was no association between BDNF and AIMS scores (p = 0.57) or TD (p = 0.65) in Asians. Conclusion: Although there was no significant association between BDNF Val66Met polymorphism and TD or AIMS scores across all patients, our results suggest that BDNF Val66Met polymorphism affects severity and, possibly, TD development in Caucasians. Since the number of studies and patients was still small, additional data are needed to confirm genotype-racial interactions. Furthermore, BDNF enhancing treatments for TD may require further study, especially in Caucasians. (C) 2013 Elsevier B.V. All rights reserved.
Volume Number
152
Issue Number
2-3
Pages
365-372
Document Type
Article
EPub Date
2014/01/15
Status
Faculty, Northwell Researcher
Facility
School of Medicine; Northwell Health
Primary Department
Psychiatry
Additional Departments
Molecular Medicine
PMID
DOI
10.1016/j.schres.2013.12.011