Quality of life and outcomes in patients60 years of age after allogeneic hematopoietic cell transplantation
Publication Date
2014
Journal Title
Bone Marrow Transplant
Abstract
Hematopoietic cell transplantation (HCT) has become an established standard of care for many older patients with hematologic malignancies. The effect of transplantation on the quality of life (QOL) of older patients, however, has not been well studied. We thus analyzed QOL in patients 60 undergoing an allogeneic HCT compared with patients(FACT-BMT), Coping Inventory and the Profile of Mood State-Short Form. Patients 60 reported better social (P=0.006) and functional well-being (P=0.05) with FACT assessment, and had better total scores, (P=0.043) across all time points. When adjusted for baseline QOL scores as a covariate, social well-being remained significantly better, whereas the other scores became non-significant. With a median follow-up of 49 months, there were no significant differences in OS, relapse-free survival, relapse or chronic GVHD. This study provides further evidence that advanced age should not be a barrier in the decision to pursue allogeneic HCT. Older patients achieved comparable QOL when compared with younger patients.
Volume Number
49
Issue Number
11
Pages
1426-31
Document Type
Article
EPub Date
2014/07/30
Status
Faculty
Facility
School of Medicine
Primary Department
Obstetrics and Gynecology
PMID
DOI
10.1038/bmt.2014.166