Reset osmostat in pregnancy: a case report

Publication Date

2014

Journal Title

J Matern Fetal Neonatal Med

Abstract

The reset osmostat syndrome, a form of inappropriate antidiuretic hormone secretion (SIADH), occurs when the threshold for antidiuretic hormone secretion is moved downward. There is evidence to suggest a "reset osmostat phenomenon'' in normal pregnancies, whereby the average plasma-osmolality is decreased by 5-10 mOsm/kg. We present a case of a non-physiologic reset osmostat in a pregnant patient, thought to be caused by large intracranial arteriovenous malformations and intraventricular hemorrhage. The presence of a reset osmostat should be suspected in any patient with apparent SIADH who has mild hyponatremia that is stable over many days despite variations in sodium and water intake. Therapeutic efforts to raise the serum sodium concentration appear to be unnecessary.

Volume Number

27

Issue Number

5

Pages

530-533

Document Type

Article

EPub Date

2013/07/19

Status

Faculty, Northwell Researcher

Facility

School of Medicine; Northwell Health

Primary Department

Obstetrics and Gynecology

Additional Departments

Radiology

PMID

23859494

DOI

10.3109/14767058.2013.819333

Full Text for Zucker SOM at Hofstra/Northwell
For the public and Northwell Health campuses

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