Application of an OCT data-based mathematical model of the foveal pit in Parkinson disease
Publication Date
2014
Journal Title
J Neural Transm (Vienna).
Abstract
Spectral-domain Optical coherence tomography (OCT) has shown remarkable utility in the study of retinal disease and has helped to characterize the fovea in Parkinson disease (PD) patients. We developed a detailed mathematical model based on raw OCT data to allow differentiation of foveae of PD patients from healthy controls. Of the various models we tested, a difference of a Gaussian and a polynomial was found to have "the best fit". Decision was based on mathematical evaluation of the fit of the model to the data of 45 control eyes versus 50 PD eyes. We compared the model parameters in the two groups using receiver-operating characteristics (ROC). A single parameter discriminated 70 % of PD eyes from controls, while using seven of the eight parameters of the model allowed 76 % to be discriminated. The future clinical utility of mathematical modeling in study of diffuse neurodegenerative conditions that also affect the fovea is discussed.
Volume Number
121
Issue Number
11
Pages
1367-1376
Document Type
Article
Status
Northwell Researcher
Facility
Northwell Health
Primary Department
Neurology
PMID
DOI
10.1007/s00702-014-1214-2