A Clinical Trial of Progesterone for Severe Traumatic Brain Injury
Publication Date
2014
Journal Title
N Engl J Med
Abstract
BACKGROUND Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. We investigated the efficacy and safety of progesterone in a large, prospective, phase 3 randomized clinical trial. METHODS We conducted a multinational placebo-controlled trial, in which 1195 patients, 16 to 70 years of age, with severe TBI (Glasgow Coma Scale score,
Volume Number
371
Issue Number
26
Pages
2467-2476
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Neurosurgery
PMID
DOI
10.1056/NEJMoa1411090