Publication Date
2014
Journal Title
Immunity
Abstract
Sepsis, a clinical syndrome occurring in patients following infection or injury, is a leading cause of morbidity andmortality worldwide. Current immunological mechanisms do not explain the basis of cellular dysfunction and organ failure, the ultimate cause of death. Here we review current dogma and argue that it is time to delineate novel immunometabolic and neurophysiological mechanisms underlying the altered cellular bioenergetics and failure of epithelial and endothelial barriers that produce organ dysfunction and death. These mechanisms might hold the key to future therapeutic strategies.
Volume Number
40
Issue Number
4
Pages
464-476
Document Type
Article
EPub Date
2014/04/22
Status
Faculty
Facility
School of Medicine
Primary Department
Molecular Medicine
Additional Departments
Neurosurgery
PMID
DOI
10.1016/j.immuni.2014.04.001