Multimodal imaging in a severe case of hydroxychloroquine toxicity

Publication Date

2015

Journal Title

Ophthalmic Surg Lasers Imaging Retina

Abstract

Retinal toxicity from hydroxychloroquine (HCQ) can be detected most readily on fundus autofluorescence, spectral-domain optical coherence tomography, and multifocal electroretinogram. The authors describe a case of a 60-year-old woman with a history of systemic lupus erythematosus undergoing HCQ treatment for 30 years who presented with visual loss over several years. Examination and multimodal imaging showed bilateral retinal pigment epithelium (RPE) changes in a bull's-eye distribution associated with cystoid macular edema. A novel imaging modality, multi-spectral imaging, appeared sensitive in detecting a bull's-eye pattern of RPE disturbance involving the entire macular region of both eyes. Cessation of drug was advised with close follow-up.

Volume Number

46

Issue Number

3

Pages

377-9

Document Type

Article

EPub Date

2015/04/10

Status

Northwell Researcher

Facility

Northwell Health

Primary Department

Ophthalmology

PMID

25856825

DOI

10.3928/23258160-20150323-14

Comments

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