Title
Multimodal imaging in a severe case of hydroxychloroquine toxicity
Publication Date
2015
Journal Title
Ophthalmic Surg Lasers Imaging Retina
Abstract
Retinal toxicity from hydroxychloroquine (HCQ) can be detected most readily on fundus autofluorescence, spectral-domain optical coherence tomography, and multifocal electroretinogram. The authors describe a case of a 60-year-old woman with a history of systemic lupus erythematosus undergoing HCQ treatment for 30 years who presented with visual loss over several years. Examination and multimodal imaging showed bilateral retinal pigment epithelium (RPE) changes in a bull's-eye distribution associated with cystoid macular edema. A novel imaging modality, multi-spectral imaging, appeared sensitive in detecting a bull's-eye pattern of RPE disturbance involving the entire macular region of both eyes. Cessation of drug was advised with close follow-up.
Volume Number
46
Issue Number
3
Pages
377-9
Document Type
Article
EPub Date
2015/04/10
Status
Northwell Researcher
Facility
Northwell Health
Primary Department
Ophthalmology
PMID
DOI
10.3928/23258160-20150323-14
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