Publication Date
2014
Journal Title
Ophthalmology
Abstract
PURPOSE: To investigate the cone photoreceptor mosaic in eyes with pseudodrusen as evidenced by the presence of subretinal drusenoid deposits (SDD) and conventional drusen using adaptive optics (AO) imaging integrated into a multimodal imaging approach. DESIGN: Observational case series. PARTICIPANTS: Eleven patients (11 eyes) with pseudodrusen and 6 patients (11 eyes) with conventional drusen. METHODS: Consecutive patients were examined using near-infrared reflectance (IR) confocal scanning laser ophthalmoscopy (SLO) and eye-tracked spectral-domain optical coherence tomography (SD-OCT) and flood-illuminated retinal AO camera of nonconfluent pseudodrusen or conventional drusen. Correlations were made between the IR-SLO, SD-OCT, and AO images. Cone density analysis was performed on AO images within 50 x 50-mum windows in 5 regions of interest overlying and in 5 located between SDD or conventional drusen with the same retinal eccentricity. MAIN OUTCOME MEASURES: Cone densities in the regions of interest. RESULTS: The pseudodrusen correlated with subretinal accumulations of material in SD-OCT imaging and this was confirmed in the AO images. Defects in the overlying ellipsoid zone band as seen by SD-OCT were associated with SDD but not conventional drusen. The mean +/- standard deviation cone density was 8964 +/- 2793 cones/mm(2) between the SDD and 863 +/- 388 cones/mm(2) over the SDD, a 90.4% numerical reduction. By comparison the mean cone packing density was 9838 +/- 3723 cones/mm(2) on conventional drusen and 12,595 +/- 3323) cones/mm(2) between them, a 21.9% numerical reduction. The difference in cone density reduction between the two lesion types was highly significant (P
Volume Number
121
Issue Number
2
Pages
545-51
Document Type
Article
EPub Date
2013/11/05
Status
Northwell Researcher
Facility
Northwell Health
Primary Department
Ophthalmology
PMID
DOI
10.1016/j.ophtha.2013.09.026