Nitrogen Bisphosphonate-induced Orbital Inflammatory Disease: Gamma Delta T Cells - A Report and Review of 2 Cases
Publication Date
2014
Journal Title
Ophthal Plast Reconstr Surg
Abstract
With the increased use of nitrogen bisphosphonate therapy for osteoporosis, multiple myeloma, metastatic prostate carcinoma, and Paget disease, it is now recognized that orbital inflammation is a potential sequelae of treatment. To date, 15 isolated cases of orbital inflammation exist in the literature with additional 2 cases reported herein. While the precise triggering mechanism for orbital inflammation is not definitively understood, it appears that a regulatory response from gamma delta T cells is the most likely causative factor. Nitrogen bisphosphonates are a causative agent of orbital inflammatory disease. These case reports adhered to the principles of Helsinki and the Health Insurance Portability and Accountability Act.
Volume Number
30
Issue Number
4
Pages
E84-E85
Document Type
Article
Status
Northwell Researcher
Facility
Northwell Health
Primary Department
Ophthalmology
PMID
DOI
10.1097/IOP.0b013e31829f3b46