Predicting bone scan positivity after biochemical recurrence following radical prostatectomy in both hormone-naive men and patients receiving androgen-deprivation therapy: results from the SEARCH database

Authors

D. M. Moreira, Northwell Health
M. R. Cooperberg
L. E. Howard
W. J. Aronson
C. J. Kane
M. K. Terris
C. L. Amling
M. Kuchibhatla
S. J. Freedland

Publication Date

2014

Journal Title

Prostate Cancer Prostatic Dis

Abstract

BACKGROUND: To evaluate the factors associated with positive bone scans after biochemical recurrence (BCR) following radical prostatectomy in both hormone-naive subjects and subjects after androgen-deprivation therapy (ADT). METHODS: Retrospective analysis of 380 bone scans of 301 hormone-naive subjects and 214 bone scans of 137 subjects after ADT following BCR from the Shared Equal Access Regional Cancer Hospital database. Generalized estimating equations and local regression plots were used to evaluate bone scan positivity by patients' demographics, pathological features, PSA levels and kinetics. RESULTS: Among hormone-naive subjects and subjects on ADT, bone scan positivity was seen in 24 (6%) and 65 (30%) subjects, respectively. In hormone-naive subjects, the higher prescan PSA, higher PSA velocity (PSAV) and shorter PSA doubling time (PSADT) were significantly associated with positive scans (P = 0.008, P

Volume Number

17

Issue Number

1

Pages

91-96

Document Type

Article

EPub Date

2014/01/15

Status

Northwell Researcher

Facility

Northwell Health

Primary Department

Urology

PMID

24418913

DOI

10.1038/pcan.2013.59