Subcutaneous injections of low doses of humanized anti-CD20 veltuzumab: A phase I study in chronic lymphocytic leukemia

Publication Date

2015

Journal Title

Leuk Lymphoma

Abstract

To evaluate the potential of subcutaneous (SC) injections with anti-CD20 antibody veltuzumab in chronic lymphocytic leukemia (CLL), 21 patients received 80, 160, or 320 mg injections every two weeks x 4 doses (n=11) or 160 or 320 mg twice-weekly x 16 doses (n=10). Treatment was well tolerated with only occasional, mild-moderate, transient injection reactions. Lymphocytosis decreased in all patients (maximum decrease, 5-91%), with 12 patients obtaining >50% decreases. Of 14 patients with lymphadenopathy on CT imaging, 5 (36%) achieved 14-61% reductions (sum of perpendicular diameters). By NCI-WG criteria, 2 patients achieved partial responses (10%). SC veltuzumab appeared active in all dose groups, with no obvious exposure-response relationship, despite cumulative doses ranging from 320 to 5120 mg. Overall median progression-free survival was 7.7 months; 3 patients remained progression-free >1 year (2 ongoing at 2-year study completion). These data suggest further studies of SC veltuzumab in CLL are warranted.

Volume Number

57

Issue Number

4

Pages

803-11

Document Type

Article

EPub Date

2015/09/22

Status

Faculty

Facility

School of Medicine

Primary Department

Hematology/Medical Oncology

Additional Departments

Molecular Medicine

PMID

26389849

DOI

10.3109/10428194.2015.1085531

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