Outcomes following Kidney transplantation in IgA nephropathy: a UNOS/OPTN analysis
Publication Date
2015
Journal Title
Clin Transplant
Abstract
This study updates assessment of post-transplant outcomes in IgAN patients in the modern era of immunosuppression. Using UNOS/OPTN data, patients >/=18 yr of age with first kidney transplant (1/1/1999 to 12/31/2008) were analyzed. Multivariable Cox regression models and propensity score-based matching techniques were used to estimate hazard ratios (HRs) for death-censored allograft survival (DCGS) and patient survival in IgAN compared to non-IgAN. Results of multivariable regression were stratified by donor type (living vs. deceased). A total of 107, 747 recipients were included (4589 with IgAN and 103 158 with non-IgAN). Adjusted HR for DCGS showed no significant difference between IgAN and non-IgAN. IgAN had higher patient survival compared to non-IgAN (HR 0.54, 95% CI 0.47-0.62, p < 0.0001 for deceased donors; HR 0.42, 95% CI 0.33-0.54, p < 0.0001 for living donors). Propensity score-matched analysis was similar, with no significant difference in DCGS between matched groups and higher patient survival in IgAN patients compared to non-IgAN group (HR 0.54, 95% CI 0.47, 0.63; p-value
Volume Number
29
Issue Number
10
Pages
911-9
Document Type
Article
EPub Date
2015/07/21
Status
Faculty, Northwell Researcher
Facility
School of Medicine; Northwell Health
Primary Department
Nephrology
Additional Departments
Molecular Medicine
PMID
DOI
10.1111/ctr.12594