Publication Date
2015
Journal Title
Am J Kidney Dis
Abstract
The association between chronic kidney disease (CKD) and cardiovascular disease (CVD) is well established, and there is mounting evidence of interorgan cross talk that may accelerate pathologic processes and the progression of organ dysfunction in both systems. This process, termed cardiorenal syndrome (CRS) by the Acute Dialysis Quality Initiative, is considered a major health problem: patients with CKD and CVD are at much higher risk of mortality than patients with either condition alone. To date, the majority of CRS research has focused on neurohormonal mechanisms and hemodynamic alterations. However, mounting evidence suggests that abnormalities in the normal pathophysiology of the bone-mineral axis, iron, and erythropoietin play a role in accelerating CKD and CVD. The goal of this article is to review the role and interrelated effects of the bone-mineral axis and anemia in the pathogenesis of chronic CRS. (C) 2015 by the National Kidney Foundation, Inc.
Volume Number
66
Issue Number
2
Pages
196-205
Document Type
Article
EPub Date
2015/03/03
Status
Faculty
Facility
School of Medicine
Primary Department
Nephrology
PMID
DOI
10.1053/j.ajkd.2014.12.016