Publication Date

2014

Journal Title

J Neuroinflammation

Abstract

Although major depressive disorder imposes a serious public health burden and affects nearly one in six individuals in developed countries over their lifetimes, there is still no consensus on its pathophysiology. Inflammation and cytokines have emerged as a promising new avenue in depression research, and, in particular, macrophage migration inhibitory factor (MIF) has been shown to be significant in depression physiology. In this review we summarize current research on MIF and depression. We highlight the arguments for MIF as a pro-and antidepressant species and discuss the potential implications for therapeutics.

Volume Number

11

Pages

9

Document Type

Article

EPub Date

2014/01/23

Status

Faculty, SOM Student

Facility

School of Medicine

Primary Department

Molecular Medicine

Additional Departments

General Internal Medicine

PMID

24447830

DOI

10.1186/1742-2094-11-11


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