Obstructive Sleep Apnea An Unexpected Cause of Insulin Resistance and Diabetes

Authors

M. Morgenstern, Northwell Health
J. Wang, Northwell Health
N. Beatty, Northwell Health
T. Batemarco, Northwell Health
A. L. Sica, Northwell Health
H. Greenberg, Zucker School of Medicine at Hofstra/Northwell

Publication Date

2014

Journal Title

Endocrinol Metabol Clin North Am

Abstract

Obstructive sleep apnea (OSA) is prevalent with type 2 diabetes. Conversely, nondiabetic patients with OSA are at increased risk of developing insulin resistance and diabetes. These disorders independently contribute to increased cardiovascular and cerebrovascular morbidity and mortality. The pathophysiology of OSA may help explain these associations. Evidence demonstrates that treatment of OSA with continuous positive airway pressure may lead to improvement in insulin sensitivity, hemoglobin A1c, systemic hypertension, and other components of the metabolic syndrome. Recognizing and treating OSA in patients with insulin resistance or diabetes ameliorates OSA-related symptoms and improves cardiometabolic risk.

Volume Number

43

Issue Number

1

Pages

187-204

Document Type

Article

EPub Date

2014/03/04

Status

Faculty, Northwell Researcher

Facility

School of Medicine; Northwell Health

Primary Department

Pulmonary, Critical Care, and Sleep Medicine

PMID

24582098

DOI

10.1016/j.ecl.2013.09.002