Increased effectiveness of early therapy with anti-tumor necrosis factor-alpha vs an immunomodulator in children with Crohn's disease

Publication Date

2014

Journal Title

Gastroenterology

Abstract

BACKGROUND & AIMS: Standard therapy for children newly diagnosed with Crohn's disease (CD) includes early administration of immunomodulators after initial treatment with corticosteroids. We compared the effectiveness of early (30; and median C-reactive protein level 5.6-fold the upper limit of normal), we used propensity score methodology to identify 68 triads of patients matched for baseline characteristics who were treated with early anti-TNFalpha therapy, early immunomodulator, or no early immunotherapy. We evaluated relationships among therapies, corticosteroid and surgery-free remission (pediatric CD activity index scores,

Volume Number

146

Issue Number

2

Pages

383-91

Document Type

Article

EPub Date

2013/10/29

Status

Faculty

Facility

School of Medicine

Primary Department

General Pediatrics

PMID

24162032

DOI

10.1053/j.gastro.2013.10.027

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