Treatment of FSGS in Children

Publication Date

2014

Journal Title

Adv Chronic Kidney Dis

Abstract

Focal segmental glomerulosclerosis (FSGS) is a pathologic condition that represents many disease entities. The goals of therapy are to cure the disease. When this is not possible, the secondary goals are to reduce proteinuria to avoid the complications of nephrotic syndrome and to delay progression of kidney disease. Proteinuria remission is one of the most important independent predictors of kidney survival. Children with FSGS who do not achieve partial or complete remission have a 50% risk of progression to ESRD within 5 years whereas those who enter complete remission have a 5-year kidney survival rate of 90%. Treatment of idiopathic FSGS commonly involves immune-based and nonimmunologic therapy options. This manuscript will review the current state of FSGS therapy for children.

Volume Number

21

Issue Number

2

Pages

194-9

Document Type

Article

EPub Date

2014/03/08

Status

Faculty

Facility

School of Medicine

Primary Department

General Pediatrics

PMID

24602468

DOI

10.1053/j.ackd.2014.01.010

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