Regulating innate immunity with dopamine and electroacupuncture

Publication Date

2014

Journal Title

Nat Med

Abstract

Neural circuits are able to modulate immune responses by detecting inflammatory mediators and relaying signals back to the immune system. Here, in a mouse model of sepsis, the authors show that the immune responses can be modulated by electroacupuncture, which stimulates a neural circuit that results in the release of dopamine. The mechanism, like the inflammatory reflex, is neither sympathetic nor parasympathetic. Their results show a potential way forward in developing therapies for sepsis in dopamine agonists (pages 291-295).

Volume Number

20

Issue Number

3

Pages

239-241

Document Type

Article

EPub Date

2014/03/08

Status

Faculty

Facility

School of Medicine

Primary Department

Molecular Medicine

Additional Departments

Neurosurgery

PMID

24603793

DOI

10.1038/nm.3501

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