Lupus brain fog: a biologic perspective on cognitive impairment, depression, and fatigue in systemic lupus erythematosus
Publication Date
2015
Journal Title
Immunol Res
Abstract
Cognitive disturbances, mood disorders and fatigue are common in SLE patients with substantial adverse effects on function and quality of life. Attribution of these clinical findings to immune-mediated disturbances associated with SLE remains difficult and has compromised research efforts in these areas. Improved understanding of the role of the immune system in neurologic processes essential for cognition including synaptic plasticity, long term potentiation and adult neurogenesis suggests multiple potential mechanisms for altered central nervous system function associated with a chronic inflammatory illness such as SLE. This review will focus on the biology of cognition and neuroinflammation in normal circumstances and potential biologic mechanisms for cognitive impairment, depression and fatigue attributable to SLE.
Volume Number
63
Issue Number
1-3
Pages
26-37
Document Type
Article
EPub Date
2015/10/21
Status
Faculty
Facility
School of Medicine
Primary Department
Molecular Medicine
Additional Departments
Allergy and Immunology
PMID
DOI
10.1007/s12026-015-8716-3