A spoonful of sugar helps lymphoma cells go up

Publication Date

2015

Journal Title

Blood

Abstract

In this issue of Blood, Schneider et al(1) document that sugar moieties, introduced into surface-membrane immunoglobulin (smIg) antigen-binding sites on follicular lymphoma (FL) cells by somatic hypermutation (SHM), induce smIg-mediated signals in a distinct, nonstandard manner. This signaling results from the sugar physically interacting with sugar-specific lectins from bacteria. The findings confirm and support the clinical relevance of previous observations about SHM introducing glycans into the variable domains of FL antigen-binding sites,X2-5 and they support the potential importance of microbial exposure to lymphomagenesis and disease progression.

Volume Number

125

Issue Number

21

Pages

3215-3216

Document Type

Article

EPub Date

2015/05/23

Status

Faculty

Facility

School of Medicine

Primary Department

Molecular Medicine

Additional Departments

General Internal Medicine

PMID

25999440

DOI

10.1182/blood-2015-04-636209

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