Title
Ixazomib-induced cutaneous necrotizing vasculitis
Publication Date
2018
Journal Title
Support Care Cancer
Abstract
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Ixazomib is a second-generation proteasome inhibitor that has been approved in the combination treatment of multiple myeloma and is currently under clinical investigation for the management of Waldenstrom’s macroglobulinemia. While cutaneous adverse events secondary to proteasome inhibitors have been reported, the side effect profile of ixazomib remains to be documented. We report two patients, one with multiple myeloma and one with Waldenstrom’s macroglobulinemia, who developed cutaneous necrotizing vasculitis after the initiation of ixazomib. Both patients exhibited no signs of systemic vasculitis and completed their anti-cancer regimens with resolution of their respective eruptions following dose reductions in ixazomib and initiation of low-dose prednisone. A collaborative effort towards the characterization of such cutaneous toxicities facilitates early intervention, maintenance of life-preserving anti-cancer therapy, and allows clinicians opportunity to better understand the pathophysiology of vasculitis. Moreover, appropriate identification and characterization of cutaneous toxicities from novel therapies allows providers to accurately identify safety concerns, treat toxicity, and improve patient quality of life.
Volume Number
26
Issue Number
7
Pages
2247 - 2250
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Dermatology
PMID
DOI
10.1007/s00520-018-4052-1