Ixazomib-induced cutaneous necrotizing vasculitis

Publication Date

2018

Journal Title

Support Care Cancer

Abstract

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Ixazomib is a second-generation proteasome inhibitor that has been approved in the combination treatment of multiple myeloma and is currently under clinical investigation for the management of Waldenstrom’s macroglobulinemia. While cutaneous adverse events secondary to proteasome inhibitors have been reported, the side effect profile of ixazomib remains to be documented. We report two patients, one with multiple myeloma and one with Waldenstrom’s macroglobulinemia, who developed cutaneous necrotizing vasculitis after the initiation of ixazomib. Both patients exhibited no signs of systemic vasculitis and completed their anti-cancer regimens with resolution of their respective eruptions following dose reductions in ixazomib and initiation of low-dose prednisone. A collaborative effort towards the characterization of such cutaneous toxicities facilitates early intervention, maintenance of life-preserving anti-cancer therapy, and allows clinicians opportunity to better understand the pathophysiology of vasculitis. Moreover, appropriate identification and characterization of cutaneous toxicities from novel therapies allows providers to accurately identify safety concerns, treat toxicity, and improve patient quality of life.

Volume Number

26

Issue Number

7

Pages

2247 - 2250

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Dermatology

PMID

29392482

DOI

10.1007/s00520-018-4052-1

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