Neurons Are the Inflammatory Problem

Authors

K. J. Tracey, Zucker School of Medicine at Hofstra/Northwell

Publication Date

2018

Journal Title

Cell

Abstract

© 2018 The discovery that reflex neuronal circuits control immunity provided a new mechanistic understanding of infection and injury. Pinho-Ribeiro et al. (2018) report that lethal tissue destruction from streptococcal necrotizing fasciitis (“flesh-eating disease”) occurs because sensory neurons reflexively inhibit frontline immune responses. The discovery that reflex neuronal circuits control immunity provided a new mechanistic understanding of infection and injury. Pinho-Ribeiro et al. (2018) report that lethal tissue destruction from streptococcal necrotizing fasciitis (“flesh-eating disease”) occurs because sensory neurons reflexively inhibit frontline immune responses.

Volume Number

173

Issue Number

5

Pages

1066 - 1068

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Neurosurgery

Additional Departments

Molecular Medicine

PMID

29775588

DOI

10.1016/j.cell.2018.05.005