Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts.

Publication Date

2019

Journal Title

J Natl Cancer Inst

Abstract

BACKGROUND: Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize risk are unknown. Current Institute of Medicine (IOM) vitamin D guidance is based solely on bone health.

METHODS: We pooled participant-level data from 17 cohorts, comprising 5706 colorectal cancer case participants and 7107 control participants with a wide range of circulating 25(OH)D concentrations. For 30.1% of participants, 25(OH)D was newly measured. Previously measured 25(OH)D was calibrated to the same assay to permit estimating risk by absolute concentrations. Study-specific relative risks (RRs) for prediagnostic season-standardized 25(OH)D concentrations were calculated using conditional logistic regression and pooled using random effects models.

RESULTS: Compared with the lower range of sufficiency for bone health (50-

CONCLUSIONS: Higher circulating 25(OH)D was related to a statistically significant, substantially lower colorectal cancer risk in women and non-statistically significant lower risk in men. Optimal 25(OH)D concentrations for colorectal cancer risk reduction, 75-100 nmol/L, appear higher than current IOM recommendations.

Volume Number

111

Issue Number

2

Pages

158-169

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Occupational Medicine, Epidemiology, and Prevention

PMID

29912394

DOI

10.1093/jnci/djy087

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