Publication Date
2018
Journal Title
Eur Radiol
Abstract
PURPOSE: Summarise survival of patients with resected lung cancers manifesting as part-solid nodules (PSNs).
METHODS: PubMed/MEDLINE and EMBASE databases were searched for all studies/clinical trials on CT-detected lung cancer in English before 21 December 2015 to identify surgically resected lung cancers manifesting as PSNs. Outcome measures were lung cancer-specific survival (LCS), overall survival (OS), or disease-free survival (DFS). All PSNs were classified by the percentage of solid component to the entire nodule diameter into category PSNs
RESULTS: Twenty studies reported on PSNs
CONCLUSION: A clear definition of the upper limit of solid component of a PSN is needed to avoid misclassification because cell-types and outcomes are different for PSN and solid nodules. The workup should be based on the size of the solid component.
KEY POINTS: • Lung cancers manifesting as PSNs are slow growing with high cure rates. • Upper limits of the solid component are important for correct interpretation. • Consensus definition is important for the management of PSNs. • Median disease-free-survival (DFS) increased with decreasing size of the nodule.
Volume Number
28
Issue Number
2
Pages
747-759
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Occupational Medicine, Epidemiology, and Prevention
PMID
DOI
10.1007/s00330-017-4975-9