Best practice considerations for using the selectivity factor, s, as a metric for the efficiency of kinetic resolutions

Publication Date

2018

Journal Title

Tetrahedron

Abstract

© 2018 Elsevier Ltd The suitability of using the selectivity factor, s, as a metric for kinetic resolution reactions and the errors associated with its measurement are considered. Investigation of the analytical error associated with HPLC analysis of a kinetic resolution reveals that one of the largest potential sources of variation arises from the ability of a practitioner to integrate the peaks from a single analysis. The consequences of this error on the reliability of reported s values are discussed, and some general rules for good practice regarding the use and reporting of s as a metric are suggested.

Volume Number

74

Issue Number

38

Pages

5554 - 5560

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Urology

DOI

10.1016/j.tet.2018.05.069

For the public and Northwell Health campuses

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