Title
Best practice considerations for using the selectivity factor, s, as a metric for the efficiency of kinetic resolutions
Publication Date
2018
Journal Title
Tetrahedron
Abstract
© 2018 Elsevier Ltd The suitability of using the selectivity factor, s, as a metric for kinetic resolution reactions and the errors associated with its measurement are considered. Investigation of the analytical error associated with HPLC analysis of a kinetic resolution reveals that one of the largest potential sources of variation arises from the ability of a practitioner to integrate the peaks from a single analysis. The consequences of this error on the reliability of reported s values are discussed, and some general rules for good practice regarding the use and reporting of s as a metric are suggested.
Volume Number
74
Issue Number
38
Pages
5554 - 5560
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Urology
DOI
10.1016/j.tet.2018.05.069