Publication Date
2015
Journal Title
Evid Based Complement Alternat Med
Abstract
High mobility group box 1 (HMGB1) is an evolutionarily conserved protein and is constitutively expressed in virtually all types of cells. In response to microbial infections, HMGB1 is secreted from activated immune cells to orchestrate rigorous inflammatory responses. Here we review the distinct mechanisms by which several herbal components inhibit HMGB1 action or secretion, such as by modulating inflammasome activation, autophagic degradation, or endocytic uptake. In light of the reciprocal interactions between these cellular processes, it is possible to develop more effective combinational herbal therapies for the clinical management of inflammatory diseases.
Volume Number
2015
Pages
456305
Document Type
Article
EPub Date
2015/03/31
Status
Faculty, Northwell Researcher
Facility
School of Medicine; Northwell Health
Primary Department
Emergency Medicine
Additional Departments
Molecular Medicine; Surgery
PMID
DOI
10.1155/2015/456305