Title
Management of lamotrigine overdose using hemodialysis
Publication Date
2019
Journal Title
Am J Emerg Med
Abstract
© 2019 Elsevier Inc. Lamotrigine [LTG] is primarily an anti-epileptic drug used to treat seizure disorders, depression, and bipolar disease. It is generally well tolerated with limited side effects reported during routine use. Adverse events after overdose include neurotoxicity in the form of sedation and seizure activity, as well as cardiopulmonary toxicity in the form of sodium-channel blockade and cardiovascular collapse. There is no consensus regarding the role of hemodialysis (HD) in management of lamotrigine toxicity. Based on pharmacological properties, LTG is a candidate for extracorporeal removal, however, the successful use of HD for the treatment of this poisoning is not well described. We report the case of a 44 year-old female after a LTG overdose that experienced prolonged sedation that was ultimately treated with HD with an excellent response.
Volume Number
37
Issue Number
8
Pages
1603.e1 - 1603.e2
Document Type
Article
Status
Faculty; Northwell Resident
Facility
School of Medicine; Northwell Health
Primary Department
Emergency Medicine
PMID
DOI
10.1016/j.ajem.2019.05.026