Management of lamotrigine overdose using hemodialysis

Publication Date

2019

Journal Title

Am J Emerg Med

Abstract

© 2019 Elsevier Inc. Lamotrigine [LTG] is primarily an anti-epileptic drug used to treat seizure disorders, depression, and bipolar disease. It is generally well tolerated with limited side effects reported during routine use. Adverse events after overdose include neurotoxicity in the form of sedation and seizure activity, as well as cardiopulmonary toxicity in the form of sodium-channel blockade and cardiovascular collapse. There is no consensus regarding the role of hemodialysis (HD) in management of lamotrigine toxicity. Based on pharmacological properties, LTG is a candidate for extracorporeal removal, however, the successful use of HD for the treatment of this poisoning is not well described. We report the case of a 44 year-old female after a LTG overdose that experienced prolonged sedation that was ultimately treated with HD with an excellent response.

Volume Number

37

Issue Number

8

Pages

1603.e1 - 1603.e2

Document Type

Article

Status

Faculty, Northwell Resident

Facility

School of Medicine; Northwell Health

Primary Department

Emergency Medicine

PMID

31109780

DOI

10.1016/j.ajem.2019.05.026

For the public and Northwell Health campuses

Share

COinS