Novel HMGA2-YAP1 fusion gene in aggressive angiomyxoma
Publication Date
2019
Journal Title
BMJ Case Rep
Abstract
© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ. We describe a case of a 44-year-old woman with locally advanced aggressive angiomyxoma with a novel translocation high-mobility group AT-hook 2-yes-associated protein 1 (HMGA2-YAP1) fusion, implying a t(11;12)(q22.1;q14.3) translocation. She was started on gonadotropin-releasing hormone agonist injection and an aromatase inhibitor for persistent disease, which responded to treatment; she was subsequently treated with radiation before a more definitive operation was conducted. This case report indicates that HGMA2-YAP1-translocated aggressive angiomyxoma is responsive to oestrogen antagonism and hopefully will allow for the development of diagnostics useful for this rare but often morbid neoplasm. This case also highlights the importance of appropriate workup of a soft tissue mass.
Volume Number
12
Issue Number
5
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Hematology/Medical Oncology
Additional Departments
Pathology and Laboratory Medicine
PMID
DOI
10.1136/bcr-2018-227475