Quality of Life in Hypoparathyroidism Improves with rhPTH(1-84) Throughout 8 Years of Therapy
Publication Date
2019
Journal Title
J Clin Endocrinol Metab
Abstract
© 2019 Endocrine Society. Calcium and vitamin D treatment does not improve reduced quality of life (QOL) in hypoparathyroidism. Recombinant human (rh) PTH(1-84) therapy improves QOL metrics for up to 5 years. Data on QOL beyond this time point are not available. Objectives: To evaluate the effects of 8 years of rhPTH(1-84) therapy on QOL and factors associated with long-term benefit. Design: Prospective, open-label trial. Setting: Referral center. Patients: Twenty patients with hypoparathyoidism. Main Outcome Measures: RAND 36-Item Short Form Health Survey (SF-36). Results: rhPTH therapy led to substantial improvement in five of the eight SF-36 domains [vitality, social functioning (SF), mental health (MH), bodily pain (BP) and general health] and three of these domains (SF, MH, BP) were no longer lower than the reference population. The improvement in the mental component summary (MCS) score was sustained through 8 years, while the physical component summary (PCS) score improved through 6 years. A lower baseline QOL score was associated with greater improvement. A threshold value ,238 (MCS) and ,245 (PCS) predicted long-term improvement in 90% and 100% of the cohort, respectively. In patients whose calcium supplementation was reduced, MCS and PCS scores improved more than those whose supplementation did not decline to the same extent. Improvement in PCS was greater in patients whose calcitriol dosage was reduced and duration of disease was shorter.
Volume Number
104
Issue Number
7
Pages
2748 - 2756
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Endocrinology, Diabetes, and Metabolism
PMID
DOI
10.1210/jc.2018-02430