Publication Date
2019
Journal Title
Cells
Abstract
Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions. Interest in AQP4 has increased since it was discovered to be the target antigen in the inflammatory autoimmune disease neuromyelitis optica spectrum disorder (NMOSD). Emerging data suggest that AQP4 may also be implicated in the glymphatic system and may be involved in the clearance of beta-amyloid in Alzheimer's disease (AD). In this review, we will describe the role of AQP4 in the adult and developing brain as well as its implication for disease.
Volume Number
8
Issue Number
2
Pages
E90
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Molecular Medicine
PMID
DOI
10.3390/cells8020090