Publication Date
2019
Journal Title
Front Neurosci
Abstract
© 2019 Caravaca, Gallina, Tarnawski, Tracey, Pavlov, Levine and Olofsson. Neural reflexes regulate inflammation and electrical activation of the vagus nerve reduces inflammation in models of inflammatory disease. These discoveries have generated an increasing interest in targeted neurostimulation as treatment for chronic inflammatory diseases. Data from the first clinical trials that use vagus nerve stimulation (VNS) in treatment of rheumatoid arthritis and Crohn’s disease suggest that there is a therapeutic potential of electrical VNS in diseases characterized by excessive inflammation. Accordingly, there is an interest to further explore the molecular mechanisms and therapeutic potential of electrical VNS in a range of experimental settings and available genetic mouse models of disease. Here, we describe a method for electrical VNS in experimental inflammation in mice.
Volume Number
13
Pages
877
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Neurosurgery
Additional Departments
Molecular Medicine
PMID
DOI
10.3389/fnins.2019.00877