Proarrhythmic Manifestations of Neuromuscular Dystrophinopathies.

Publication Date

2020

Journal Title

Cardiol Rev

Abstract

Muscular dystrophy has been an elusive term ever since it was first described in the 19 century. Introduced in 1891 by Wilhem Heinrich Erb, muscular dystrophy has been classified as part of a larger group of genetically-determined, progressive degenerative neuromuscular disorders termed "dystrophinopathies." Cardiac arrhythmias may occur during the neurologic course of the disease. Although descriptions of the dystrophinopathies have been reported in the literature, few articles address the use of antiarrhythmic pharmacotherapy in patients with muscular dystrophy. We discuss the pathophysiology of the most common dystrophinopathies, their proarrhythmic sequelae, and the therapeutic use of antiarrhythmic agents in the clinical setting.

Document Type

Article

Status

Faculty, SOM Student

Facility

School of Medicine

Primary Department

Cardiology

PMID

32068541

DOI

10.1097/crd.0000000000000305

For the public and Northwell Health campuses

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