TMEM173 Drives Lethal Coagulation in Sepsis

Publication Date

2020

Journal Title

Cell Host Microbe

Abstract

© 2020 Elsevier Inc. Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.

Volume Number

27

Issue Number

4

Pages

556 - 570

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Emergency Medicine

PMID

32142632

DOI

10.1016/j.chom.2020.02.004

For the public and Northwell Health campuses

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