Title
TMEM173 Drives Lethal Coagulation in Sepsis
Publication Date
2020
Journal Title
Cell Host Microbe
Abstract
© 2020 Elsevier Inc. Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.
Volume Number
27
Issue Number
4
Pages
556 - 570
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Emergency Medicine
PMID
DOI
10.1016/j.chom.2020.02.004