TMEM173 Drives Lethal Coagulation in Sepsis
Cell Host Microbe
© 2020 Elsevier Inc. Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.
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School of Medicine