Anifrolumab in systemic lupus erythematosus: Current knowledge and future considerations

Publication Date

2020

Journal Title

Immunotherapy

Abstract

© 2020 Future Medicine Ltd. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is potentially life-Threatening and can affect any organ. The complex pathogenesis and heterogeneity of the disease, among other factors, present significant challenges in developing new therapies. Knowledge gained over many years has implicated type I interferon (IFN) in the pathogenesis of SLE and anti-IFN therapies hold promise as a much-needed future treatment for SLE. Anifrolumab, a human monoclonal antibody against the type I IFN receptor, has recently been evaluated in two Phase III clinical trials for the treatment of moderate-To-severe SLE. Here, we review the clinical efficacy and safety of anifrolumab and discuss the potential challenges in determining the optimal SLE patient subgroup for treatment.

Volume Number

12

Issue Number

5

Pages

275 - 286

Document Type

Article

Status

Faculty, Northwell Resident

Facility

School of Medicine; Northwell Health

Primary Department

Rheumatology

PMID

32237942

DOI

10.2217/imt-2020-0017

Comments

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