Using the Mouse to Model Human Diseases: Cognitive Impairment in Systemic Lupus Erythematosus

Publication Date

2020

Journal Title

J Rheumatol

Abstract

Cognitive impairment (CI) is one of the most prevalent neuropsychiatric syndromes. In Systemic Lupus Erythematosus (SLE) Patients often report CI as the most bothersome disease-related manifestation with a great impact on their quality of life. Nevertheless, studies focusing on CI remain scarce and no effective targeted therapy has been identified. We herein present murine models of CI in lupus with insights into the pathogenesis of this condition as well as the role of the renin angiotensin system in microglial activation. We will discuss the role of neuroimaging as a useful objective assessment tool describing our experience in previous and ongoing clinical trials of CI in SLE patients.

Volume Number

47

Issue Number

7

Pages

1145-1149

Document Type

Article

Status

Faculty, Northwell Resident

Facility

School of Medicine; Northwell Health

Primary Department

Molecular Medicine

Additional Departments

Rheumatology

PMID

32295852

DOI

10.3899/jrheum.200410

For the public and Northwell Health campuses

Share

COinS