Using the Mouse to Model Human Diseases: Cognitive Impairment in Systemic Lupus Erythematosus
Publication Date
2020
Journal Title
J Rheumatol
Abstract
Cognitive impairment (CI) is one of the most prevalent neuropsychiatric syndromes. In Systemic Lupus Erythematosus (SLE) Patients often report CI as the most bothersome disease-related manifestation with a great impact on their quality of life. Nevertheless, studies focusing on CI remain scarce and no effective targeted therapy has been identified. We herein present murine models of CI in lupus with insights into the pathogenesis of this condition as well as the role of the renin angiotensin system in microglial activation. We will discuss the role of neuroimaging as a useful objective assessment tool describing our experience in previous and ongoing clinical trials of CI in SLE patients.
Volume Number
47
Issue Number
7
Pages
1145-1149
Document Type
Article
Status
Faculty, Northwell Resident
Facility
School of Medicine; Northwell Health
Primary Department
Molecular Medicine
Additional Departments
Rheumatology
PMID
DOI
10.3899/jrheum.200410