Synchronous Presence of EGFR, ALK Driver Mutations Along With PD L1 Overexpression in a Resected Early Stage Non-Small Cell Lung Cancer: A Case Report and Review of Literature.

Authors

N. Thumallapally, Northwell Health
S. Parylo, Northwell Health
A. Vennepureddy, Northwell Health
U. Ibrahim, Northwell Health
A. Sokoloff, Zucker School of Medicine at Hofstra/Northwell

Publication Date

2018

Journal Title

World J Oncol

Abstract

Treatment of lung cancer has been revolutionized with development of drugs that target key driver mutations and immune checkpoints. Until recently, it was believed that these driver mutations are mutually exclusive. However, few reports have emerged citing the presence of both mutations either synchronously or metachronously. We describe a case report of lung adenocarcinoma harboring two driver mutations in the same tumor cells as well as exhibiting high PDL1 expression. We further discuss the possible association of these driver mutations with PDL1 expression.

Volume Number

9

Issue Number

2

Pages

50 - 55

Document Type

Article

Status

Faculty, Northwell Researcher, Northwell Resident

Facility

School of Medicine; Northwell Health

Primary Department

Hematology/Medical Oncology

PMID

29760833

DOI

10.14740/wjon1090e