Title
Recent advance in molecular angiogenesis in glioblastoma: the challenge and hope for anti-angiogenic therapy
Publication Date
2015
Journal Title
Brain Tumor Pathol
Abstract
Glioblastoma (GBM) is the most highly malignant brain tumor in the human central nerve system. In this paper, we review new and significant molecular findings on angiogenesis and possible resistance mechanisms. Expression of a number of genes and regulators has been shown to be upregulated in GBM microvessel cells, such as interleukin-8, signal transducer and activator of transcription 3, Tax-interacting protein-1, hypoxia induced factor-1 and anterior gradient protein 2. The regulator factors that may strongly promote angiogenesis by promoting endothelial cell metastasis, changing the microenvironment, enhancing the ability of resistance to anti-angiogenic therapy, and that inhibit angiogenesis are reviewed. Based on the current knowledge, several potential targets and strategies are proposed for better therapeutic outcomes, such as its mRNA interference of DII4-Notch signaling pathway and depletion of b1 integrin expression. We also discuss possible mechanisms underlying the resistance to anti-angiogenesis and future directions and challenges in developing new targeted therapy for GBM.
Volume Number
32
Issue Number
4
Pages
229-36
Document Type
Article
EPub Date
2015/10/07
Status
Faculty
Facility
Northwell Health
Primary Department
Pathology and Laboratory Medicine
PMID
DOI
10.1007/s10014-015-0233-5