Similarities and Differences Between Nonalcoholic Steatohepatitis and Other Causes of Cirrhosis

Publication Date

2020

Journal Title

Gastroenterol Clin North Am

Abstract

© 2019 Elsevier Inc. Nonalcoholic fatty liver disease includes a spectrum of liver disorders that range from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Risk factors such as obesity, hypertension, hyperlipidemia, chronic kidney disease, and smoking status increase risk of progression to cirrhosis among patients with NASH. Cirrhosis derived from non-NASH causes may share similar features with patients with NASH but embody distinct pathogenetic mechanisms, genetic associations, prognosis, and outcomes. This article discusses in detail the comparison of clinical, genetic, and outcome characteristics between patients with NASH cirrhosis as opposed to alternative causes of chronic liver disease.

Volume Number

49

Issue Number

1

Pages

151 - 164

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Hepatology

PMID

32033761

DOI

10.1016/j.gtc.2019.09.004

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