Post-COVID-19 Cholangiopathy: A Novel Entity.
Publication Date
2021
Journal Title
Am J Gastroenterol
Abstract
Introduction
Liver chemistry abnormalities are a frequent manifestation of coronavirus disease 2019 (COVID-19) but are usually transient and resolve with disease resolution.
Methods
We describe the clinical course and histologic features of 3 adults who developed prolonged and severe cholestasis during recovery from critical cardiopulmonary COVID-19.
Results
These patients had clinical and histologic features similar to secondary sclerosing cholangitis of the critically ill patient, but with unique histologic features including severe cholangiocyte injury and intrahepatic microangiopathy suggestive of direct hepatic injury from COVID-19.
Discussion
We believe that these cases constitute a novel severe post-COVID-19 cholangiopathy with potential for long-term hepatic morbidity.
Document Type
Article
Status
Faculty, Northwell Resident
Facility
School of Medicine; Northwell Health
Primary Department
Hepatology
Additional Departments
Pathology and Laboratory Medicine; Science Education; COVID-19 Publications
PMID
DOI
10.14309/ajg.0000000000001154