Cyto-Immuno-Therapy for Cancer: A Pathway Elicited by Tumor-Targeted, Cytotoxic Drug-Packaged Bacterially Derived Nanocells
Publication Date
2020
Journal Title
Cancer Cell
Abstract
© 2020 Elsevier Inc. Sagnella et al. report the immune modulatory effects of EnGeneIC Dream Vectors (EDVs), bacterially derived nonviable nanocells bearing cytotoxic payloads, in mouse models and human cancer patients. In addition to cytotoxicity, EDVs induce innate and adaptive immune responses to elicit antitumor effects.
Volume Number
37
Issue Number
3
Pages
354 - 370
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Neurosurgery
Additional Departments
Otolaryngology
PMID
DOI
10.1016/j.ccell.2020.02.001