Title
EWSR1 and ATF1 rearrangements in clear cell odontogenic carcinoma: presentation of a case
Publication Date
2014
Journal Title
Oral Surg Oral Med Oral Pathol Oral Radiol
Abstract
Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws that is more common in the mandible than maxilla and has a female preponderance with a peak incidence in the sixth decade. It is characterized by locally aggressive behavior and has the potential to metastasize. This tumor was recently reported to have a rearrangement of the Ewing sarcoma breakpoint region 1 gene (EWS RNA-binding protein 1, EWSR1) in 5 of 8 cases tested and of the activating transcription factor 1 gene (ATF1) in 1 case tested. We report a case of CCOC in the premolar area of the mandible in a 59-year-old woman. This case demonstrated the presence of both EWSR1 and ATF1 gene rearrangements by fluorescence in situ hybridization.
Volume Number
118
Issue Number
4
Pages
E115-E118
Document Type
Article
EPub Date
2014/04/12
Status
Faculty, Northwell Researcher
Facility
School of Medicine; Northwell Health
Primary Department
Pathology and Laboratory Medicine
Additional Departments
Dental Medicine
PMID
DOI
10.1016/j.oooo.2014.02.004